Article
Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia.
Developmental biology - 1 Aug 1999
Prowse D M, Lee D, Weiner L, Jiang N, Magro C M, Baden H P, Brissette J L
Abstract excerpt
Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. In murine epidermis and hair follicles, endogenous whn expression is induced as epithelial cells initiate terminal differentiation. Using the promoter for the differentiation marker...
Topics
- Animals
- Calcium
- Cell Culture Techniques
- Cell Differentiation
- Cell Division
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Epithelium
- Eye Abnormalities
- Forkhead Transcription Factors
- Humans
- Keratinocytes
- Mice