Article
Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus.
International immunology - 1 Jun 1996
Kurooka H, Segre J A, Hirano Y, Nemhauser J L, Nishimura H, Yoneda K, Lander E S, Honjo T
Abstract excerpt
Mice and rats homozygous for mutations at the nude (nu) locus exhibit the pleiotropic phenotypes of hairlessness and athymia. A recent positional cloning study identified, as a nude gene, a novel fork head transcription factor, Hfh11 (also called whn), that is expressed in skin and thymus, and is...
Topics
- Animals
- Cosmids
- DNA-Binding Proteins
- Forkhead Transcription Factors
- Gene Expression Regulation
- Genetic Vectors
- Mice
- Mice, Nude
- Mice, Transgenic
- Mutagenesis, Insertional
- Phenotype
- Transcription Factors