Article
Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus.
International immunology - 1 Jun 1996
Kurooka H, Segre J A, Hirano Y, Nemhauser J L, Nishimura H, Yoneda K, Lander E S, Honjo T
Abstract excerpt
Mice and rats homozygous for mutations at the nude (nu) locus exhibit the pleiotropic phenotypes of hairlessness and athymia. A recent positional cloning study identified, as a nude gene, a novel fork head transcription factor, Hfh11 (also called whn), that is expressed in skin and thymus, and is mutated in nude rodents. To obtain the direct biological proof that this gene is responsible for nude phenotype, we...
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