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Article

The <i>nude</i> gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system

15 Apr 1997

Abstract excerpt

In the mouse, the product of the nude locus, Whn, is required for the keratinization of the hair shaft and the differentiation of epithelial progenitor cells in the thymus. A bacterially expressed peptide representing the presumptive DNA binding domain of the mouse whn gene in vitro specifically binds to a 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC. In transient transfection assays,...

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Identifiers

PMID: 9108066
DOI: 10.1073/pnas.94.8.3842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The <i>nude</i> gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune systemPMID 9108066Read ↗

New member of the winged-helix protein family disrupted in mouse and rat nude mutations.Semantic proximity Read ↗

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.Semantic proximity Read ↗

A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development.Semantic proximity Read ↗

Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotypeSemantic proximity Read ↗

Genetically separable determinants of hair keratin gene expression.Semantic proximity Read ↗

Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat.Semantic proximity Read ↗

FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.Semantic proximity Read ↗

Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling.Semantic proximity Read ↗

A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment.Semantic proximity Read ↗

The nude gene and the skin.Semantic proximity Read ↗

Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product.Semantic proximity Read ↗

Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia.Semantic proximity Read ↗

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