Article
Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat.
Genomics - 10 Aug 1995
Segre J A, Nemhauser J L, Taylor B A, Nadeau J H, Lander E S
Abstract excerpt
Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in severely compromised immune system. To identify the causative gene, we utilized modern tools and techniques of positional cloning. Specifically, spanning the region in which th...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA
- DNA, Complementary
- DNA-Binding Proteins
- Female
- Forkhead Transcription Factors
- Humans
- Male