Article
The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996
Schüddekopf K, Schorpp M, Boehm T
Abstract excerpt
Mutations in the whn gene are associated with the phenotype of congenital athymia and hairlessness in mouse and rat. The whn gene encodes a presumptive transcription factor with a DNA binding domain of the forkhead/ winged-helix class. Two previously described null alleles encode truncated whn proteins lacking the characteristic DNA binding domain. In the rat rnu allele described here, a nonsense mutation in exon...
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