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Article

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

Molecular cancer research : MCR - 1 Apr 2012

Moser Russell, Toyoshima Masafumi, Robinson Kristin, Gurley Kay E, Howie Heather L, Davison Jerry, Morgan Martin, Kemp Christopher J, Grandori Carla

Abstract excerpt

MYC-induced DNA damage is exacerbated in WRN-deficient cells, leading to replication stress and accelerated cellular senescence. To determine whether WRN deficiency impairs MYC-driven tumor development, we used both xenograft and autochthonous tumor models. Conditional silencing of WRN expression in c-MYC overexpressing non-small cell lung cancer xenografts impaired both tumor establishment and tumor growth. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22301954
DOI: 10.1158/1541-7786.MCR-11-0508
PMCID: PMC3707802

Genes

WRN
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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