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Article

WRN at telomeres: implications for aging and cancer.

Journal of cell science - 1 Mar 2007

Multani Asha S, Chang Sandy

Abstract excerpt

Werner Syndrome (WS) is a premature aging syndrome characterized by early onset of age-related pathologies and cancer. Since WS is due to a single gene defect, it has attracted much interest from researchers seeking to understand pathways that contribute to cancer and aging at cellular and molecular levels. The protein mutated in WS, WRN, appears to play a major role in genome stability, particularly during DNA...

Topics

Aging
Animals
Exodeoxyribonucleases
Humans
Models, Biological
Mutation
Neoplasms
RecQ Helicases
Telomere
Werner Syndrome
Werner Syndrome Helicase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17314245
DOI: 10.1242/jcs.03397

Genes

WRN

Provenance

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