A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).

doi:10.3892/ijmm.2013.1592

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Article

A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).

International journal of molecular medicine - 1 Feb 2014

Sugimoto Masanobu

Abstract excerpt

This perspective review focused on the Werner syndrome (WS) by addressing the issue of how a single mutation in a WRN gene encoding WRN DNA helicase induces a wide range of premature aging phenotypes accompanied by an abnormal pattern of tumors. The key event caused by WRN gene mutation is the dysfunction of telomeres. Studies on normal aging have identified a molecular circuit in which the dysfunction of...

Topics

Aging, Premature
Animals
Carcinogenesis
Cellular Senescence
DNA Helicases
Disease Models, Animal
Genes, p53
Genomic Instability
Humans
Mitochondria
Neoplasms
Oxidative Stress
Phenotype
Reactive Oxygen Species
TOR Serine-Threonine Kinases
Telomere
Werner Syndrome

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Open in PubMed

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PMID: 24356923
DOI: 10.3892/ijmm.2013.1592

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