Article
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Cancer research - 1 Mar 2001
Lebel M, Cardiff R D, Leder P
Abstract excerpt
Werner syndrome is an autosomal recessive disorder characterized by genomic instability and by the premature onset of a number of age-related diseases, including malignancy. To assess a potential collaboration between p21 or p53 cell cycle regulators and Wrn proteins, Wrn mutant mice were created and mated with p21 or p53 null mice to generate double mutants. The p21 null/Wrn mutant mice did not show an...
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