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Article

Mutations and aberrant transcriptions of Stk11 (Lkb1) gene in rat liver tumors.

Anticancer research - 1 Feb 2011

Wakabayashi Naoko, Okabe Kyoko, Hayashi Mai, Honoki Kanya, Tsujiuchi Toshifumi

Abstract excerpt

UNLABELLED: To clarify the involvement of the Stk11/Lkb1 gene in the development of hepatocellular carcinomas (HCCs), its alteration in rat HCCs induced by exogenous and endogenous liver carcinogenesis models was investigated. MATERIALS AND METHODS: Fifteen HCCs induced by N-nitrosodiethylamine (DEN) and 12 HCCs induced by a choline-deficient L-amino acid-defined (CDAA) diet were obtained. To assess mutations and...

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PMID: 21378336

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