Article
Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats.
Biochemical and biophysical research communications - 12 Oct 2007
Onishi Mariko, Sokuza Yui, Nishikawa Tomoki, Mori Chiharu, Uwataki Kimiko, Honoki Kanya, Tsujiuchi Toshifumi
Abstract excerpt
Mutations of the mitochondria DNA (mtDNA) displacement loop (D-loop) were investigated to clarify different changes of exogenous and endogenous liver carcinogenesis in rats. We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet. DNAs were extracted from 10 HCCs induced by DEN and 10 HCCs induced by the CDAA diet. To identify...
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