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Article

Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors.

Mutation research - 15 Jan 2009

Obo Yumi, Yamada Takanori, Furukawa Mami, Hotta Mayuko, Honoki Kanya, Fukushima Nobuyuki, Tsujiuchi Toshifumi

Abstract excerpt

Lysophosphatidic acid (LPA) is a bioactive phospholipid that stimulates cell proliferation, migration, and protects cells from apoptosis. It interacts with specific G protein-coupled transmembrane receptors, including LPA1 to LPA5. In the present study, to clarify an involvement of LPA1 gene alterations in the development of hepatocellular carcinomas (HCCs) we investigated the LPA1 mutations in rat HCCs induced...

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Source

Identifiers

PMID: 19000703
DOI: 10.1016/j.mrfmmm.2008.10.005

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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