Article
Targeting arrestin interactions with its partners for therapeutic purposes.
Advances in protein chemistry and structural biology - 1 Jan 2020
Gurevich Vsevolod V, Gurevich Eugenia V
Abstract excerpt
Most vertebrates express four arrestin subtypes: two visual ones in photoreceptor cells and two non-visuals expressed ubiquitously. The latter two interact with hundreds of G protein-coupled receptors, certain receptors of other types, and numerous non-receptor partners. Arrestins have no enzymatic activity and work by interacting with other proteins, often assembling multi-protein signaling complexes. Arrestin...
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