Article
Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms.
Insect biochemistry and molecular biology - 1 Nov 2008
Johnson Erik C, Tift Frank W, McCauley Anita, Liu Lingzhi, Roman Gregg
Abstract excerpt
The arrestins are a family of molecules that terminate signaling from many different G protein-coupled receptors, by inhibiting the association between receptor and downstream effectors. We recently employed a human betaarrestin2-GFP fusion protein to explore the dynamics of different neuropeptide receptors in Drosophila and have previously used a betaarrestin translocation assay to identify ligands at orphan...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.