beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

doi:10.1074/jbc.M506576200

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Article

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

The Journal of biological chemistry - 13 Jan 2006

Shenoy Sudha K, Drake Matthew T, Nelson Christopher D, Houtz Daniel A, Xiao Kunhong, Madabushi Srinivasan, Reiter Eric, Premont Richard T, Lichtarge Olivier, Lefkowitz Robert J

Abstract excerpt

Physiological effects of beta adrenergic receptor (beta2AR) stimulation have been classically shown to result from G(s)-dependent adenylyl cyclase activation. Here we demonstrate a novel signaling mechanism wherein beta-arrestins mediate beta2AR signaling to extracellular-signal regulated kinases 1/2 (ERK 1/2) independent of G protein activation. Activation of ERK1/2 by the beta2AR expressed in HEK-293 cells was...

Topics

Amino Acid Sequence
Animals
Arrestins
COS Cells
Cattle
Cell Line
Cell Membrane
Chlorocebus aethiops
Cyclic AMP
Evolution, Molecular
G-Protein-Coupled Receptor Kinase 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

G-Protein-Coupled Receptor Kinases

GTP-Binding Proteins

Humans

Iodocyanopindolol

Isoquinolines

Kinetics

Mice

Source

Open in PubMed

Identifiers

PMID: 16280323
DOI: 10.1074/jbc.M506576200

Genes

GRK5
GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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