Article
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
Science (New York, N.Y.) - 19 Jan 1996
Ferguson S S, Downey W E, Colapietro A M, Barak L S, Ménard L, Caron M G
Abstract excerpt
beta-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by uncoupling the signal transduction process. Resensitization of GPCR responsiveness involves agonist-mediated receptor seq...
Topics
- Adrenergic beta-Agonists
- Antigens
- Arrestins
- Cell Line
- Cyclic AMP-Dependent Protein Kinases
- DNA, Complementary
- Eye Proteins
- GTP-Binding Proteins
- Humans
- Isoproterenol
- Mutation
- Phosphorylation
- Point Mutation
- Receptors, Adrenergic, beta-2
- Transfection
- beta-Adrenergic Receptor Kinases
- beta-Arrestins