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Article

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.

Science (New York, N.Y.) - 19 Jan 1996

Ferguson S S, Downey W E, Colapietro A M, Barak L S, Ménard L, Caron M G

Abstract excerpt

beta-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by uncoupling the signal transduction process. Resensitization of GPCR responsiveness involves agonist-mediated receptor sequestration. Overexpression of beta-arrestins in human embryonic kidney cells rescued the sequestration of beta...

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Identifiers

PMID: 8553074
DOI: 10.1126/science.271.5247.363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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