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Article

GRK2-mediated receptor phosphorylation and Mdm2-mediated β-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors.

Biochemical and biophysical research communications - 10 Dec 2020

Zhang Xiaohan, Zheng Mei, Kim Kyeong-Man

Abstract excerpt

Clathrin-mediated and caveolar endocytic pathways represent the major routes through which G protein-coupled receptors (GPCRs) could be internalized. GPCR kinase 2 (GRK2) and β-arrestins are representative proteins that mediate the GPCR endocytosis. However, the molecular mechanisms through which GRK2 and β-arrestin mediate clathrin-mediated and caveolar endocytosis remain unclear. In this study, we determined...

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Identifiers

PMID: 32962859
DOI: 10.1016/j.bbrc.2020.09.030

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