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Article

Conformational stability is a determinant of ribonuclease A cytotoxicity.

The Journal of biological chemistry - 9 Jun 2000

Klink T A, Raines R T

Abstract excerpt

Onconasetrade mark, a homolog of bovine pancreatic ribonuclease A (RNase A) with high conformational stability, is cytotoxic and has efficacy as a cancer chemotherapeutic agent. Unlike wild-type RNase A, the G88R variant is toxic to cancer cells. Here, variants in which disulfide bonds were removed from or added to G88R RNase A were used to probe the relationship between conformational stability and cytotoxicity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Erythroblastic, Acute

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Share to Ribonuclease, Pancreatic

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Source

Identifiers

PMID: 10747991
DOI: 10.1074/jbc.M001132200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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