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Article

Onconase cytotoxicity relies on the distribution of its positive charge.

The FEBS journal - 1 Jul 2009

Turcotte Rebecca F, Lavis Luke D, Raines Ronald T

Abstract excerpt

Onconase (ONC) is a member of the ribonuclease A superfamily that is toxic to cancer cells in vitro and in vivo. ONC is now in Phase IIIb clinical trials for the treatment of malignant mesothelioma. Internalization of ONC to the cytosol of cancer cells is essential for its cytotoxic activity, des...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 19523116
DOI: 10.1111/j.1742-4658.2009.07098.x
PMCID: PMC2754565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19523116-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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