Article
A ribonuclease A variant with low catalytic activity but high cytotoxicity.
The Journal of biological chemistry - 7 Apr 2000
Bretscher L E, Abel R L, Raines R T
Abstract excerpt
Onconase, a homolog of ribonuclease A (RNase A) with low ribonucleolytic activity, is cytotoxic and has efficacy as a cancer chemotherapeutic. Here variants of RNase A were used to probe the interplay between ribonucleolytic activity and evasion of the cytosolic ribonuclease inhibitor protein (RI) in the cytotoxicity of ribonucleases. K41R/G88R RNase A is a less active catalyst than G88R RNase A but,...
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