Engineering of ovine pancreatic RNase A as an Anti-tumor agent through in silico and experimental approaches.

Abstract excerpt

Ovine RNase A (O-RNase A) is a promising candidate due to its effectiveness as a toxin. It is an effective variant of bovine RNase A, with four specific mutations (A19S, K37Q, V46F, and N103E). RNase A families are inhibited by RNase inhibitors; if RNase A evades these, it can function as a toxin in immunotoxins. In this research, our goal is to prevent the inhibition of the O-RNase A enzyme. We designed four...

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