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Article

Generation of new cytotoxic human ribonuclease variants directed to the nucleus.

Molecular pharmaceutics - 1 Oct 2012

Vert Anna, Castro Jessica, Ruiz-Martínez Santiago, Tubert Pere, Escribano Diego, Ribó Marc, Vilanova Maria, Benito Antoni

Abstract excerpt

Ribonucleases are promising agents for use in anticancer therapy. Engineering a nuclear localization signal into the sequence of the human pancreatic ribonuclease has been revealed as a new strategy to endow this enzyme with cytotoxic activity against tumor cells. We previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which is able to cleave nuclear RNA, inducing the apoptosis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22957849
DOI: 10.1021/mp300217b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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