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Article

New muteins of RNase A with enhanced antitumor action.

FEBS letters - 16 Oct 1998

Cafaro V, Bracale A, Di Maro A, Sorrentino S, D'Alessio G, Di Donato A

Abstract excerpt

Monomeric bovine pancreatic RNase A has been transformed into a dimeric ribonuclease with antitumor activity (Di Donato, A., Cafaro, V. and D'Alessio, G. (1994) J. Biol. Chem. 269, 17394-17396). This was accomplished by replacing the residues located in the RNase chain at positions 19, 28, 31, and 32, with proline, leucine, and two cysteine residues, respectively, i.e. those present at identical positions in the...

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Source

Identifiers

PMID: 9804190
DOI: 10.1016/s0014-5793(98)01221-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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