New muteins of RNase A with enhanced antitumor action.

doi:10.1016/s0014-5793(98)01221-6

Back to search

Article

New muteins of RNase A with enhanced antitumor action.

FEBS letters - 16 Oct 1998

Cafaro V, Bracale A, Di Maro A, Sorrentino S, D'Alessio G, Di Donato A

Abstract excerpt

Monomeric bovine pancreatic RNase A has been transformed into a dimeric ribonuclease with antitumor activity (Di Donato, A., Cafaro, V. and D'Alessio, G. (1994) J. Biol. Chem. 269, 17394-17396). This was accomplished by replacing the residues located in the RNase chain at positions 19, 28, 31, an...

Topics

Animals
Antineoplastic Agents
Cattle
Cell Survival
Mutagenesis, Site-Directed
Mutation
Protein Engineering
Ribonuclease, Pancreatic
Tumor Cells, Cultured

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.