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Article

Structural changes to ribonuclease A and their effects on biological activity.

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology - 1 Jun 1999

Soucek J, Raines R T, Haugg M, Raillard-Yoon S A, Benner S A

Abstract excerpt

Bovine seminal ribonuclease (BS RNase) displays immunosuppressive and antitumor activities on mammalian cells, whereas bovine pancreatic ribonuclease (RNase A) is not cytotoxic. To learn more about the mechanism of BS RNase cytotoxicity, various mutants and hybrid proteins were prepared. A series of RNase A variants substituted with amino acid residues from BS RNase were prepared. Concerning quaternary structure,...

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Identifiers

PMID: 10442819
DOI: 10.1016/s0742-8413(99)00005-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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