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Article

Disruption of the putative vascular leak peptide sequence in the stabilized ricin vaccine candidate RTA1-33/44-198.

Toxins - 30 Jan 2013

Janosi Laszlo, Compton Jaimee R, Legler Patricia M, Steele Keith E, Davis Jon M, Matyas Gary R, Millard Charles B

Abstract excerpt

Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this potentially toxic site within the more stable RTA1-33/44-198 vaccine immunogen and determined the impact of these...

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Identifiers

PMID: 23364220
DOI: 10.3390/toxins5020224
PMCID: PMC3640533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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