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Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression

1 Mar 2000

Abstract excerpt

The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited invasiveness of the highly invasive cell lines, suggesting an invasion-promoting role of PKC in human RCC. Analysis of PKC-isoenzyme expression by protein fractionation and immunoblotting revealed that all...

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PMID: 10737390
DOI: 10.1054/bjoc.1999.1043

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