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Article

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

Oncogene - 1 Aug 1993

Cacace A M, Guadagno S N, Krauss R S, Fabbro D, Weinstein I B

Abstract excerpt

We have overproduced the Ca(2+)-independent protein kinase C isoform, nPKC epsilon, in Rat 6 embryo fibroblasts, and examined the effects of this novel isoform on cell growth and transformation. As compared to vector control cell lines expressing only the hygromycin resistance gene, the nPKC epsilon overproducing cell lines exhibited a 7-13-fold increase in Ca(2+)-independent enzyme activity. Detailed analysis of...

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PMID: 8336936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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