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Article

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.

Annals of neurology - 1 Jul 2003

Al-Chalabi Ammar, Scheffler Margaret D, Smith Bradley N, Parton Matthew J, Cudkowicz Merit E, Andersen Peter M, Hayden Douglas L, Hansen Valerie K, Turner Martin R, Shaw Christopher E, Leigh P Nigel, Brown Robert H

Abstract excerpt

Ciliary neurotrophic factor (CNTF) maintains survival of adult motor neurons. Mice lacking the CNTF gene develop mild, progressive motor neuron loss. In the normal human population, 1 to 2.3% are homozygous for a null allele, and reports suggest this mutant is associated with a younger onset of a...

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Source

Identifiers

PMID: 12838531
DOI: 10.1002/ana.10638

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12838531-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.PMID 12838531Read ↗

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A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

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