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Article

Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.

The Journal of physiology - 15 Mar 2000

Clarke C E, Benham C D, Bridges A, George A R, Meadows H J

Abstract excerpt

1. Effects of external pH on the human P2X4 purinoceptor, an ATP-activated ion channel, were studied using the Xenopus oocyte expression system. 2. Changing the external pH from 7.4 to 6.5 significantly reduced, whilst an increase to pH 8 enhanced, maximum ATP-activated current amplitude, without changing the current- voltage relationship of the ATP-activated current. 3. Diethyl pyrocarbonate (DEPC; 10 mM)...

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Identifiers

PMID: 10718748
DOI: 10.1111/j.1469-7793.2000.00697.x
PMCID: PMC2269823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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