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Article

Role of extracellular histidines in agonist sensitivity of the rat P2X4 receptor.

Neuroscience letters - 29 Jul 2004

Xiong Keming, Stewart Randall R, Hu Xiang-Qun, Werby Elena, Peoples Robert W, Weight Forrest F, Li Chaoying

Abstract excerpt

Relatively little information is available about the relationship between the molecular structure of each of the seven subtypes of P2X receptors and their function. Here, we investigated the possible function of three histidine residues in the extracellular loop of rat P2X(4) receptors. Mutation of histidine 241 to alanine (H241A) in the rat P2X(4) receptor decreased the EC(50) value of the ATP...

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Source

Identifiers

PMID: 15246547
DOI: 10.1016/j.neulet.2004.04.078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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