Article
pH-dependent modulation of the cloned renal K+ channel, ROMK.
The American journal of physiology - 1 Dec 1998
McNicholas C M, MacGregor G G, Islas L D, Yang Y, Hebert S C, Giebisch G
Abstract excerpt
pH is an important modulator of the low-conductance ATP-sensitive K+ channel of the distal nephron. To examine the mechanism of interaction of protons with the channel-forming protein, we expressed the cloned renal K channel, ROMK (Kir1.x), in Xenopus oocytes and examined the response to varied c...
Topics
- Acids
- Adenosine Triphosphate
- Animals
- Cloning, Molecular
- Electric Conductivity
- Female
- Hydrogen
- Hydrogen-Ion Concentration
- Kinetics
- Mutation
- Oocytes
- Potassium Channel Blockers
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Protons
- Xenopus laevis