Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

pH-dependent modulation of the cloned renal K+ channel, ROMK.

The American journal of physiology - 1 Dec 1998

McNicholas C M, MacGregor G G, Islas L D, Yang Y, Hebert S C, Giebisch G

Abstract excerpt

pH is an important modulator of the low-conductance ATP-sensitive K+ channel of the distal nephron. To examine the mechanism of interaction of protons with the channel-forming protein, we expressed the cloned renal K channel, ROMK (Kir1.x), in Xenopus oocytes and examined the response to varied concentrations of protons both in the presence and in the absence of ATP. Initial experiments were performed on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Cloning, Molecular
Share to Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Mutation

Share to Oocytes

Share to Potassium Channels

Share to Xenopus laevis

Source

Identifiers

PMID: 9843915
DOI: 10.1152/ajprenal.1998.275.6.F972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

pH-dependent modulation of the cloned renal K+ channel, ROMK.PMID 9843915Read ↗

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.Semantic proximity Read ↗

Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.Semantic proximity Read ↗

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.Semantic proximity Read ↗

Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.Semantic proximity Read ↗

Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.Semantic proximity Read ↗

An ATP-regulated, inwardly rectifying potassium channel from rat kidney (ROMK).Semantic proximity Read ↗

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.Semantic proximity Read ↗

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.Semantic proximity Read ↗

Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domains.Semantic proximity Read ↗

Involvement of histidine residues in proton sensing of ROMK1 channel.Semantic proximity Read ↗

Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.