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Article

A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.

The Journal of biological chemistry - 2 Mar 2001

Zong X, Stieber J, Ludwig A, Hofmann F, Biel M

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels control the rhythmic activity of heart and neuronal networks. The activation of these channels is regulated in a complex manner by hormones and neurotransmitters. In addition it was suggested that the channels may be controlled by the pH of the cytosol. Here we demonstrate that HCN2, a member of the HCN channel family, is directly modulated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11096117
DOI: 10.1074/jbc.M010326200

Genes

HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.PMID 11096117Read ↗

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Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel.Semantic proximity Read ↗

Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Semantic proximity Read ↗

Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation.Semantic proximity Read ↗

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 ChannelSemantic proximity Read ↗

Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1.Semantic proximity Read ↗

Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity.Semantic proximity Read ↗

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Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.Semantic proximity Read ↗

Gating mechanism of hyperpolarization-activated HCN pacemaker channels.Semantic proximity Read ↗

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