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Article

Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2003

Mott David D, Washburn Mark S, Zhang Sunan, Dingledine Raymond J

Abstract excerpt

Synaptic activity causes significant fluctuations in proton concentrations in the brain. Changes in pH can affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamate. We show here a subunit-dependent regulation of native and recombinant kainate receptors by physiologically relevant proton concentrations. The effect of protons on kainate receptors is voltage-independent and...

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Identifiers

PMID: 12598606
PMCID: PMC6742282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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