Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines.

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Article

Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2003

Mott David D, Washburn Mark S, Zhang Sunan, Dingledine Raymond J

Abstract excerpt

Synaptic activity causes significant fluctuations in proton concentrations in the brain. Changes in pH can affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamate. We show here a subunit-dependent regulation of native and recombinant kainate receptors by physiologically relevant proton concentrations. The effect of protons on kainate receptors is voltage-independent and...

Topics

Animals
Cell Line
Cells, Cultured
Drug Synergism
Electric Conductivity
Hippocampus
Humans
Hydrogen-Ion Concentration
Kinetics
Mutation
Patch-Clamp Techniques
Polyamines
Protein Subunits
Protons
Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 12598606
PMCID: PMC6742282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Sprague-Dawley

Receptors, Kainic Acid

Recombinant Proteins