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Article

Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH.

American journal of physiology. Cell physiology - 1 Feb 2007

Stewart A K, Kurschat C E, Burns D, Banger N, Vaughan-Jones R D, Alper S L

Abstract excerpt

Activity of the AE2/SLC4A2 anion exchanger is modulated acutely by pH, influencing the transporter's role in regulation of intracellular pH (pH(i)) and epithelial solute transport. In Xenopus oocytes, heterologous AE2-mediated Cl(-)/Cl(-) and Cl(-)/HCO(3)(-) exchange are inhibited by acid pH(i) or extracellular pH (pH(o)). We have investigated the importance to pH sensitivity of the eight histidine (His) residues...

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Identifiers

PMID: 17005605
DOI: 10.1152/ajpcell.00265.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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