Article
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Molecular and cellular biology - 1 Apr 2000
Zhou S, Fujimuro M, Hsieh J J, Chen L, Miyamoto A, Weinmaster G, Hayward S D
Abstract excerpt
Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the nucleus, where it targets the DNA binding protein CBF1. CBF1 mediates transcriptional repression through the recruitment of an SMRT-histone deacetylase-containing corepressor complex. We have examined the mechanism...
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