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Article

Gene-specific targeting of the histone chaperone asf1 to mediate silencing.

Developmental cell - 1 Oct 2007

Goodfellow Henry, Krejcí Alena, Moshkin Yuri, Verrijzer C Peter, Karch Francois, Bray Sarah J

Abstract excerpt

The histone chaperone Asf1 assists in chromatin assembly and remodeling during replication, transcription activation, and gene silencing. However, it has been unclear to what extent Asf1 could be targeted to specific loci via interactions with sequence-specific DNA-binding proteins. Here, we show that Asf1 contributes to the repression of Notch target genes, as depletion of Asf1 in cells by RNAi causes...

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Identifiers

PMID: 17925233
DOI: 10.1016/j.devcel.2007.08.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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