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Article

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.

Nature communications - 30 Nov 2017

Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Watase Kei, Homma Hidenori, Tagawa Kazuhiko, Sudol Marius, Okazawa Hitoshi

Abstract excerpt

YAP and its neuronal isoform YAPdeltaC are implicated in various cellular functions. We found that expression of YAPdeltaC during development, but not adulthood, rescued neurodegeneration phenotypes of mutant ataxin-1 knock-in (Atxn1-KI) mice. YAP/YAPdeltaC interacted with RORα via the second WW domain and served as co-activators of its transcriptional activity. YAP/YAPdeltaC formed a transcriptional complex with...

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Identifiers

PMID: 29192206
DOI: 10.1038/s41467-017-01790-z
PMCID: PMC5709507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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