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Article

Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.

Molecular and cellular biology - 1 Sept 2001

Zhou S, Hayward S D

Abstract excerpt

The CSL family protein CBF1 is a nuclear mediator of Notch signaling and has been predicted to contain an N-terminal nuclear localization signal in exon 4. Surprisingly, we found that CBF1 carrying mutations at codon 233 or 249 within exon 7 was restricted to the cytoplasm. In mammalian and yeast two-hybrid assays, these mutations were also associated with a loss of CBF1-mediated transcriptional repression and a...

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Identifiers

PMID: 11509665
DOI: 10.1128/MCB.21.18.6222-6232.2001
PMCID: PMC87339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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