Article
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.
Mutation research - 9 May 2001
Anensen H, Provan F, Lian A T, Reinertsen S H, Ueno Y, Matsuda A, Seeberg E, Bjelland S
Abstract excerpt
5-Formyluracil (5-foU) is a major oxidation product of thymine formed in yields comparable to that of 8-oxoguanine in DNA by ionizing radiation. Whereas the mutagenic effects of 8-oxoguanine are well understood, the investigation of the biological implications of 5-foU has so far been limited. Here we demonstrate that 5-formyl-2'-deoxyuridine (5-fodUrd) supplied to the growth medium of Escherichia coli induces...
Topics
- Base Pair Mismatch
- Base Sequence
- DNA Damage
- DNA Mutational Analysis
- DNA, Bacterial
- Deoxyuridine
- Escherichia coli
- Genes, Bacterial
- Lac Operon
- Models, Chemical
- Mutagenesis
- Mutation