Article
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.
Mutation research - 9 May 2001
Anensen H, Provan F, Lian A T, Reinertsen S H, Ueno Y, Matsuda A, Seeberg E, Bjelland S
Abstract excerpt
5-Formyluracil (5-foU) is a major oxidation product of thymine formed in yields comparable to that of 8-oxoguanine in DNA by ionizing radiation. Whereas the mutagenic effects of 8-oxoguanine are well understood, the investigation of the biological implications of 5-foU has so far been limited. Here we demonstrate that 5-formyl-2'-deoxyuridine (5-fodUrd) supplied to the growth medium of Escherichia coli induces...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.