Article
Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998
Kreutzer D A, Essigmann J M
Abstract excerpt
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the oxidized lesion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol, were investigated in Escherichia coli. An M13 viral genome was constructed to contain a single oxidized cytosine at a specific site....
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