Article
Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998
Kreutzer D A, Essigmann J M
Abstract excerpt
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the oxidized lesion(s) that gives rise to this mutation, the mutagenicity of three oxidized cytosines, 5-hydroxycytosine, 5-hydroxyuracil, and uracil glycol, were investigat...
Topics
- Cytosine
- DNA Damage
- DNA Replication
- DNA, Viral
- Escherichia coli
- Genome, Viral
- Mutagenesis
- Mutation
- Oxidation-Reduction
- Oxidative Stress