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Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells.

DNA repair - 1 May 2009

Satou Kazuya, Hori Mika, Kawai Kazuaki, Kasai Hiroshi, Harashima Hideyoshi, Kamiya Hiroyuki

Abstract excerpt

The mutagenicity of an oxidized form of dGTP, 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (8-OH-dGTP), was examined using human 293T cells. Shuttle plasmid DNA containing the supF gene was first transfected into the cells, and then 8-OH-dGTP was introduced by means of osmotic pressure. The DNAs replicated in the cells were recovered and then transfected into Escherichia coli. 8-OH-dGTP induced A:T-->C:G...

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Identifiers

PMID: 19179121
DOI: 10.1016/j.dnarep.2008.12.009

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REV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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