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Article

The missing linkage: what pharmacogenetic associations are left to find in CYP3A?

Expert opinion on drug metabolism & toxicology - 1 Jan 2010

Perera Minoli A

Abstract excerpt

IMPORTANCE OF THE FIELD: An enormous amount of drugs and endogenous substrates are metabolized by the enzymes encoded in the CYP3A gene cluster, making variation at this locus of utmost importance in the field of pharmacogenetics. However, the identification of genetic variation that contributes to the wide phenotypic variability at this locus has been elusive. While dozens of studies have investigated the...

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PMID: 19968573
DOI: 10.1517/17425250903379546

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