Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ESC-E(Z) complex participates in the hedgehog signaling pathway.

Biochemical and biophysical research communications - 25 Feb 2005

Shindo Norihisa, Sakai Atsushi, Arai Daisuke, Matsuoka Osamu, Yamasaki Yukihiko, Higashinakagawa Toru

Abstract excerpt

Polycomb group (PcG) genes are required for stable inheritance of epigenetic states throughout development, a phenomenon termed cellular memory. In Drosophila and mice, the product of the E(z) gene, one of the PcG genes, constitutes the ESC-E(Z) complex and specifically methylates histone H3. It has been argued that this methylation sets the stage for appropriate repression of certain genes. Here, we report the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fish Proteins
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Hydroxamic Acids

Share to Lysine

Share to Methylation

Share to Multiprotein Complexes

Share to Oryzias

Source

Identifiers

PMID: 15652519
DOI: 10.1016/j.bbrc.2004.12.125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ESC-E(Z) complex participates in the hedgehog signaling pathway.PMID 15652519Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.Semantic proximity Read ↗

A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC.Semantic proximity Read ↗

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.Semantic proximity Read ↗

Polycomb group proteins ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development.Semantic proximity Read ↗

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.Semantic proximity Read ↗

The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.Semantic proximity Read ↗

The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.Semantic proximity Read ↗

E(z): a polycomb group gene or a trithorax group gene?Semantic proximity Read ↗

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Semantic proximity Read ↗

Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila.Semantic proximity Read ↗

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.