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Article

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.

Diabetes - 1 Apr 2009

Escribano Oscar, Guillén Carlos, Nevado Carmen, Gómez-Hernández Almudena, Kahn C Ronald, Benito Manuel

Abstract excerpt

OBJECTIVE: Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO). RESEARCH DESIGN AND METHODS: Using this approach, we were able to induce variable insulin receptor (IR) deficiency in a tissue-specific manner...

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Identifiers

PMID: 19136656
DOI: 10.2337/db08-0551
PMCID: PMC2661585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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