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Article

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes.

Nature clinical practice. Endocrinology & metabolism - 1 Mar 2008

Leroith Derek, Accili Domenico

Abstract excerpt

A wide range of genetically engineered murine models of type 2 diabetes have been created to try to understand the site of the primary defect in insulin action, and the relationship between insulin resistance and impaired beta-cell function in diabetes. Genetic disruption of various aspects known to be important in diabetes has examined specific facets, including glucose sensing, transcription factors for the...

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Share to Diabetes Mellitus, Type 2
Share to Disease Models, Animal
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout

Share to Receptor, IGF Type 1

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Source

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Identifiers

PMID: 18212763
DOI: 10.1038/ncpendmet0729
PMCID: PMC2714226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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