Article
Genetic modifiers of the insulin resistance phenotype in mice.
Diabetes - 1 Apr 2000
Kido Y, Philippe N, Schäffer A A, Accili D
Abstract excerpt
Insulin resistance can result from genetic interactions among susceptibility alleles. To identify genetic loci predisposing to insulin resistance, we used crosses between different strains of mice with a targeted null allele of the insulin receptor gene. On the genetic background of B6 mice, the insulin receptor gene mutation causes mild hyperinsulinemia. In contrast, on the genetic background of 129/Sv mice, the...
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