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Article

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2000

Accili D, Nakae J, Kim J J, Park B C, Rother K I

Abstract excerpt

Insulin-like growth factors (IGFs) and their receptors regulate embryonic and post-natal growth. Genetic evidence derived from targeted mouse mutants indicates that both the insulin receptor (IR) and IGF-I receptors (IGF-IRs) are required for mouse embryonic growth. However, the roles of IRs and IGF-IRs are functionally distinct, with IGF-IRs mediating both IGF-I and IGF-II actions, and IRs mediating IGF-II,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10417963
DOI: 10.1515/jpem.1999.12.4.475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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