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Article

Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.

American journal of physiology. Endocrinology and metabolism - 1 Jun 2007

Kim Jane J, Kido Yoshiaki, Scherer Philipp E, White Morris F, Accili Domenico

Abstract excerpt

Type 2 diabetes results from impaired insulin action and beta-cell dysfunction. There are at least two components to beta-cell dysfunction: impaired insulin secretion and decreased beta-cell mass. To analyze how these two variables contribute to the progressive deterioration of metabolic control seen in diabetes, we asked whether mice with impaired beta-cell growth due to Irs2 ablation would be able to mount a...

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Source

Identifiers

PMID: 17299086
DOI: 10.1152/ajpendo.00430.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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