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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

Cell - 21 Feb 1997

Brüning J C, Winnay J, Bonner-Weir S, Taylor S I, Accili D, Kahn C R

Abstract excerpt

NIDDM is a polygenic disease characterized by insulin resistance in muscle, fat, and liver, followed by a failure of pancreatic beta cells to adequately compensate for this resistance despite increased insulin secretion. Mice double heterozygous for null alleles in the insulin receptor and insuli...

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Alleles
Disease Models, Animal
Genotype
Heterozygote
Liver
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

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PMID: 9038347
DOI: 10.1016/s0092-8674(00)81896-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9038347-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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