Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs.

doi:10.1002/(SICI)1098-2272(200002)18:2<97::AID-GEPI1>3.0.CO;2-J

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Article

Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs.

Genetic epidemiology - 1 Feb 2000

Guo X, Elston R C

Abstract excerpt

Two-stage global search designs for linkage analysis using pairs of affected relatives were shown by Elston et al. [1996] to typically halve the cost of a study compared to a one-stage design. The statistic used for testing linkage in that study was based on the proportion of pairs sharing no mar...

Topics

Alleles
Genes, Dominant
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetic Variation
Humans
Models, Statistical

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