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Article

Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs.

Genetic epidemiology - 1 Feb 2000

Guo X, Elston R C

Abstract excerpt

Two-stage global search designs for linkage analysis using pairs of affected relatives were shown by Elston et al. [1996] to typically halve the cost of a study compared to a one-stage design. The statistic used for testing linkage in that study was based on the proportion of pairs sharing no marker alleles identical by descent (IBD). However, it has been established that the mean statistic often has the greatest...

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PMID: 10642424
DOI: 10.1002/(SICI)1098-2272(200002)18:2<97::AID-GEPI1>3.0.CO;2-J

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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